P-15 enhances bone formation by facilitating cellular attachment with subsequent increase in cell binding, proliferation, and differentiation of cells increasing TGFb-1, BMP-2, and BMP-7 levels that positively influence all processes of new bone formation.


i-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone.

i-FACTOR increases the opportunity for cell binding in the fusion site by making an abundance of P-15 available to osteogenic cells. The ability of P-15 to enhance cell binding hastens the process of new bone formation and closely resembles the natural process of bone regeneration. Once cells attach, to the P-15 immobilised on the ABM substrate, the cascade of events leading to new bone formation commences.

IDE Study

i-FACTOR Bone Graft shown to be superior to autograft based on analysis of patient response to all four clinical endpoints from the pivotal IDE trial.

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