
Integrin Targeted Innovation
i-FACTOR™ bone graft is the only bone graft substitute that uses a unique anorganic bone mineral (ABM) and small peptide, P-15™, that acts as an attachment factor for specific integrins in osteogenic cells. This novel mechanism of action enhances the natural bone healing process resulting in safe, predictable bone formation at a fraction of the cost of conventional growth factors. Mechanism of Action 
NATURAL
- P-15 mimics the cell-binding domain of type I human collagen and is also responsible for osteogenic cell attachment to type 1 human collagen.
- This cell-binding will initiate the flow of mechanical and chemical information between cells and the extracellular matrix, natural bone healing occurs leading to fusion.
SAFE
- i-FACTOR bone graft provides safe, predictable bone formation and avoids the morbidity of harvesting autograft.
- i-FACTOR bone graft will only stimulate bone growth in the presence of bone forming cells.
PROVEN
- i-FACTOR bone graft has been clinically proven equivalent to autograft – the gold standard in bone regeneration.
- i-FACTOR bone graft is easy to use in a wide range of orthopedic surgical procedures.
COST EFFECTIVE
- i-FACTOR bone graft costs far less than conventional growth factors – making it economically feasible for use in all orthopedic, spine and trauma cases.
APPROVED AND READY FOR USE
- i-FACTOR bone graft bears the CE Mark and is available for sale outside the US.

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